This is a big clash in the AFC South between two teams that are off to slow starts.  The Jaguars need to get back to the basics on offense and run the football.  The Colts are allowing 181.5 yards rushing per game and they are on the small side on the interior of the defense.  With that in mind look for Fred Taylor (67 yards rushing, 2.9 ypc) and Maurice Jones-Drew (30 yards rushing, 2.5 ypc) to each have their best games of the season as long as the Jags get some push from the offensive line.  If the Jaguars get their running game going against the Colts then they can attack them through the air with play action passing.

The Colts will likely come out throwing the ball to try to get a lead and take the Jaguars out of their offense.  The Jaguars are allowing 191.0 yards passing per game so the Colts will spread out Anthony Gonzalez, Reggie Wayne and Marvin Harrison and let Peyton Manning pick who to throw to.  It would really help the Colts if they could get the running game going against the Jags which will be easier said than done as the Colts are only averaging 39.0 yards per game rushing and 2.3 yards per carry.

PREDICTION:  INDIANAPOLIS COLTS 20, JACKSONVILLE JAGUARS 13